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In fact, NO at high levels inhibits heme insertion in hemoglobin, NO synthases, and heme thiolate enzymes, such as cytochrome P450’s (CYP) in different manners (i.e., through the direct binding to the heme iron or to covalent modifications in heme transfer proteins) [147,148,149]
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More recently, other selection schemes have been implemented to improve analyte inducibility and thus the biosensor response using Ec ArsR as a model
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